Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.59 |
| ▸ | PRMT3 | O60678 | 9/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2162616 | 0.92 | IMPDH2 (0.70) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL19860124 | 0.89 | IMPDH2 (0.59) | IMPDH2PRMT3NOTUM | |
| SCHEMBL14124375 | 0.86 | ROCK1 (0.59) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL2163047 | 0.86 | NOTUM (0.65) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL19860106 | 0.85 | ROCK1 (0.57) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL2162395 | 0.85 | ROCK2 (0.61) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL19860107 | 0.84 | ROCK2 (0.57) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL19860040 | 0.83 | PRMT3 (0.53) | IMPDH2PRMT3NOTUMROCK1ROCK2 | |
| SCHEMBL14124373 | 0.83 | NOTUM (0.55) | IMPDH2PRMT3NOTUMROCK2 | |
| SCHEMBL19860042 | 0.83 | MEN1 (0.60) | IMPDH2PRMT3NOTUMROCK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |