Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.55 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860090 | 0.86 | ROCK2 (0.57) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL21430054 | 0.83 | IMPDH2 (0.62) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL3566775 | 0.83 | PRMT3 (0.72) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL2164137 | 0.81 | PRMT3 (0.69) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL4524018 | 0.80 | LMNA (0.55) | NOTUMROCK2ROCK1 | |
| SCHEMBL14124306 | 0.79 | PRMT3 (0.66) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL16634909 | 0.78 | PRMT3 (0.61) | IMPDH2NOTUMPRMT3 | |
| SCHEMBL12201759 | 0.78 | IMPDH2 (0.61) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| SCHEMBL20353549 | 0.78 | IMPDH2 (0.61) | IMPDH2NOTUMPRMT3ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL3564762 | 0.77 | IMPDH2 (0.59) | IMPDH2NOTUMPRMT3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |