Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.55 |
| ▸ | PRMT3 | O60678 | 6/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860124 | 0.90 | IMPDH2 (0.59) | IMPDH2PRMT3NOTUM | |
| SCHEMBL2162616 | 0.88 | IMPDH2 (0.70) | ROCK1ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL14124375 | 0.88 | ROCK1 (0.59) | ROCK1ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL19860042 | 0.86 | MEN1 (0.60) | ROCK2IMPDH2PRMT3NOTUMMEN1 | |
| SCHEMBL14625937 | 0.85 | ROCK2 (0.60) | ROCK1ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL19860065 | 0.85 | ROCK1 (0.61) | ROCK1ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL19860110 | 0.85 | IMPDH2 (0.59) | ROCK1ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL14136014 | 0.84 | LMNA (0.67) | ROCK2IMPDH2PRMT3NOTUMMEN1 | |
| SCHEMBL14124377 | 0.84 | PRMT3 (0.51) | ROCK2IMPDH2PRMT3NOTUMMEN1 | |
| SCHEMBL19860082 | 0.84 | ROCK1 (0.60) | ROCK1ROCK2IMPDH2PRMT3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |