SCHEMBL19862491

SCHEMBL19862491

O=C(COS(=O)(=O)C(F)(F)C(=O)Nc1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.44
NPC1 O15118 3/20 0.44
PDK1 Q15118 4/20 0.42
PDK2 Q15119 4/20 0.42
PDK3 Q15120 4/20 0.42
PDK4 Q16654 4/20 0.42
PKM P14618 1/20 0.41
MAPT P10636 5/20 0.41
MEN1 O00255 5/20 0.41
RAB9A P51151 2/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19862480 0.91 KMT2A (0.50) KMT2ANPC1PDK1PDK2PDK3
SCHEMBL19865274 0.91 HSD11B1 (0.48) KMT2ANPC1MAPTMEN1RAB9A
SCHEMBL19865277 0.89 KMT2A (0.53) KMT2ANPC1PDK1PDK2PDK3
SCHEMBL19862485 0.84 HPGD (0.46) KMT2ANPC1PDK1PDK2PDK3
SCHEMBL19862482 0.84 KCNK3 (0.43) KMT2APDK1PDK2PDK3PDK4
SCHEMBL19862481 0.82 KCNK3 (0.46) KMT2ANPC1MAPTMEN1RAB9A
SCHEMBL19865275 0.82 HDAC1 (0.40) KMT2AMAPTMEN1HDAC3HDAC4
SCHEMBL5702476 0.81 TDP1 (0.45) KMT2ANPC1MAPTMEN1RAB9A
SCHEMBL19866854 0.80 MAPT (0.39) KMT2ANPC1MAPTMEN1RAB9A
SCHEMBL19863273 0.77 FAAH (0.50) KMT2ANPC1MEN1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9983475-B2 Fluorinated sulfonate esters of aryl ketones for non-ionic photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-05-29 US disclosed
US-9983475-B2 Fluorinated sulfonate esters of aryl ketones for non-ionic photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-05-29 US disclosed
US-9950999-B2 Non-ionic low diffusing photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-9950999-B2 Non-ionic low diffusing photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-20180044284-A1 NON-IONIC LOW DIFFUSING PHOTO-ACID GENERATORS INTERNATIONAL BUSINESS MACHINES CORPORATION 2018-02-15 US disclosed
US-20180046077-A1 FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS INTERNATIONAL BUSINESS MACHINES CORPORATION 2018-02-15 US disclosed
US-20180046077-A1 FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS INTERNATIONAL BUSINESS MACHINES CORPORATION 2018-02-15 US disclosed
US-20180044284-A1 NON-IONIC LOW DIFFUSING PHOTO-ACID GENERATORS INTERNATIONAL BUSINESS MACHINES CORPORATION 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180044284-A1 NON-IONIC LOW DIFFUSING PHOTO-ACID GENERATORS PLG, PPARG, PKLR KMT2A 1672/4885NPC1 3592/4885PDK1 51/4885
US-20180046077-A1 FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS PFAS, PLG, PPARG KMT2A 1225/4885NPC1 3184/4885PDK1 372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.