Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.42 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197378 | 1.00 | NOD1 (0.53) | NOD1CA2MAPK1HDAC2CA1 | |
| SCHEMBL197377 | 1.00 | NOD1 (0.53) | NOD1CA2MAPK1HDAC2CA1 | |
| SCHEMBL11057343 | 0.93 | NOD1 (0.56) | NOD1GPR84FFAR1SLC1A2SLC1A1 | |
| Sulfuric Acid SCHEMBL5549277 | 0.92 | NOD1 (0.47) | NOD1CA2MAPK1HDAC2CA1 | |
| SCHEMBL7100031 | 0.91 | NOD1 (0.59) | NOD1GPR84FFAR1MAPTLCK | |
| SCHEMBL617558 | 0.86 | — | — | |
| SCHEMBL1604327 | 0.86 | — | — | |
| SCHEMBL2172011 | 0.86 | — | — | |
| SCHEMBL6238817 | 0.84 | CA2 (0.52) | NOD1CA2MAPK1HDAC2CA1 | |
| Butane SCHEMBL15570208 | 0.84 | HDAC1 (0.48) | NOD1CA2MAPK1HDAC2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130316409-A1 | Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them | VERENIUM CORPORATION (US) | 2013-11-28 | — | — | US | claimed |
| EP-1242589-B1 | METHODS FOR PRODUCING ENANTIOMERICALLY PURE ALPHA-SUBSTITUTED CARBOXYLIC ACIDS | VERENIUM CORP (US) | 2013-11-13 | — | — | EP | claimed |
| US-8501451-B2 | Nitrilases and methods for making and using them | VERENIUM CORPORATION (US) | 2013-08-06 | — | — | US | claimed |
| US-20120009637-A1 | Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them | VERENIUM CORPORATION (US) | 2012-01-12 | — | — | US | claimed |
| US-20120009633-A1 | NITRILASES AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION (US) | 2012-01-12 | — | — | US | claimed |
| US-8088613-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | VERENIUM CORPORATION (US) | 2012-01-03 | — | — | US | claimed |
| US-8034595-B2 | Nitrilases and methods for making and using them | VERENIUM CORPORATION (US) | 2011-10-11 | — | — | US | claimed |
| US-20090162906-A1 | Biocatalysts; mutant and/or chemically modified enzymes; stereoselectively hydrolyze an amino nitrile or cyanohydrin intermediate to produce the corresponding carboxylic acid; e.g. phenylglycinonitrile from benzaldehyde, potassium cyanide and ammonium chloride | VERENIUM CORPORATION (US) | 2009-06-25 | — | — | US | claimed |
| US-7300775-B2 | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents | VERENIUM CORPORATION (US) | 2007-11-27 | — | — | US | claimed |
| EP-1242589-A2 | METHODS FOR PRODUCING ENANTIOMERICALLY PURE ALPHA-SUBSTITUTED CARBOXYLIC ACIDS | DIVERSA CORPORATION (US) | 2002-09-25 | — | — | EP | claimed |
| US-20020012974-A1 | Genetic engineered nucleic acid promoter | VERENIUM CORPORATION | 2002-01-31 | — | — | US | claimed |
| WO-2001048175-A2 | METHODS FOR PRODUCING ENANTIOMERICALLY PURE α-SUBSTITUTED CARBOXYLIC ACIDS | DIVERSA CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |
| US-9828594-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160355801-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION | 2016-12-08 | — | — | US | disclosed |
| US-9315792-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-04-19 | — | — | US | disclosed |
| US-9217164-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| WO-2003097810-A2 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | DIVERSA CORPORATION | 2003-07-03 | — | — | US | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |
| US-20020012974-A1 | Genetic engineered nucleic acid promoter | VERENIUM CORPORATION | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009633-A1 | NITRILASES AND METHODS FOR MAKING AND USING THEM | ASNS, DNPEP, ASPH | NOD1 1952/4885CA2 44/4885MAPK1 3419/4885 |
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | NIT2, DNPH1, ASNS | NOD1 1065/4885CA2 103/4885MAPK1 4224/4885 |
| US-20090162906-A1 | Biocatalysts; mutant and/or chemically modified enzymes; stereoselectively hydrolyze an amino nitrile or cyanohydrin intermediate to produce the corresponding carboxylic acid; e.g. phenylglycinonitrile from benzaldehyde, potassium cyanide and ammonium chloride | PAH, ASPH, CPN1 | NOD1 1337/4885CA2 56/4885MAPK1 3361/4885 |
| US-20020012974-A1 | Genetic engineered nucleic acid promoter | RNGTT, ASPH, ALKBH3 | NOD1 3599/4885CA2 168/4885MAPK1 4046/4885 |
| US-20120009637-A1 | Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them | RNGTT, NSUN2, NSUN3 | NOD1 2102/4885CA2 882/4885MAPK1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.