Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374410 | 1.00 | RIPK1 (0.38) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL237269 | 0.84 | PRKCZ (0.45) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL240803 | 0.84 | PRKCZ (0.45) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL240802 | 0.84 | PRKCZ (0.45) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL1989823 | 0.84 | MAPT (0.43) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL1989751 | 0.84 | MAPT (0.43) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL14856415 | 0.84 | MAPT (0.43) | RIPK1SLC6A2SLC6A4SLC6A3PRKCZ | |
| SCHEMBL6127410 | 0.84 | NOTUM (0.42) | PRKCZHRH3CYP3A4ACHE | |
| SCHEMBL1982018 | 0.81 | F2 (0.45) | RIPK1PRKCZLMNAALOX15MAPK1 | |
| SCHEMBL1982111 | 0.80 | KIF11 (0.51) | HRH3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2337781-A2 | ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION | Abbott Laboratories (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2010144646-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |