Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19901553 | 0.85 | MGLL (0.39) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL19901555 | 0.83 | TERT (0.41) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL4761373 | 0.79 | MGLL (0.41) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL19901568 | 0.79 | PTGS1 (0.40) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL19901583 | 0.79 | AKT1 (0.43) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL4761338 | 0.78 | ALDH1A1 (0.48) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL19901565 | 0.78 | PTGS1 (0.41) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL9999885 | 0.77 | PTGS1 (0.37) | MGLLALDH1A1BLMLMNAMAPT | |
| SCHEMBL22455963 | 0.76 | OPRM1 (0.41) | MGLLALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL11887084 | 0.74 | PTGS1 (0.43) | MGLLALDH1A1BLMLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961435-B1 | CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS | IMMUNOGEN INC (US) | 2019-05-01 | — | — | EP | disclosed |
| US-9901647-B2 | Conjugates comprising cell-binding agents and cytotoxic agents | IMMUNOGEN, INC. (US) | 2018-02-27 | — | — | US | disclosed |