Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | LIG1 | P18858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840978 | 0.86 | HPGD (0.38) | TSHRGAAHPGDMAPK1HSD17B10 | |
| SCHEMBL15067115 | 0.78 | MAPT (0.35) | TSHRHTR2CHPGDMAPK1HSD17B10 | |
| SCHEMBL15068118 | 0.78 | ADRA2A (0.36) | TSHRGAAHPGDHTR2AMAPK1 | |
| SCHEMBL3523639 | 0.75 | L3MBTL1 (0.38) | TSHRCYP3A4ATMMEN1KMT2A | |
| SCHEMBL15066511 | 0.74 | HTR2C (0.39) | TSHRGAAHTR2CHPGDHTR2A | |
| SCHEMBL15066835 | 0.74 | GAA (0.37) | TSHRGAAHTR2CHPGDHTR2A | |
| SCHEMBL17460051 | 0.74 | AGER (0.35) | TSHRHPGDMAPK1HSD17B10CYP3A4 | |
| SCHEMBL10648647 | 0.72 | KMT2A (0.47) | TSHRGAAHTR2CHPGDHTR2A | |
| SCHEMBL25172614 | 0.72 | KMT2A (0.34) | HPGDMAPK1CYP2A6PTPRCKMT2A | |
| SCHEMBL11241339 | 0.71 | CA12 (0.34) | CYP3A4CYP2A6PTPRCLIG1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107033139-B | Heteroaryl piperidine and heteroaryl based piperazine derivative as fungicide | 拜耳知识产权有限责任公司 | 2019-11-19 | — | — | CN | claimed |
| US-9975889-B2 | Heteroaryl piperidine and heteroaryl piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-05-22 | — | — | US | claimed |
| US-9914728-B2 | Heteroaryl piperidine and heteroaryl piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-03-13 | — | — | US | claimed |
| CN-107033139-A | It is used as the heteroaryl piperidine and heteroaryl based piperazine derivative of fungicide | 拜耳知识产权有限责任公司 | 2017-08-11 | — | — | CN | claimed |
| US-20170044153-A1 | HETEROARYL PIPERIDINE AND HETEROARYL PIPERAZINE DERIVATIVES AS FUNGICIDES | BAYER INTELLECTUAL PROPERTY GMBH | 2017-02-16 | — | — | US | claimed |
| US-20170044154-A1 | HETEROARYL PIPERIDINE AND HETEROARYL PIPERAZINE DERIVATIVES AS FUNGICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-02-16 | — | — | US | claimed |
| EP-2516426-B1 | BIS(DIFLUORMETHYL)PYRAZOLES USED AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2015-09-16 | — | — | EP | claimed |
| US-20140057945-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-27 | — | — | US | claimed |
| US-8524743-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER CROPSCIENCE AG (DE) | 2013-09-03 | — | — | US | claimed |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-09-15 | — | — | US | claimed |
| CN-107266382-B | Heteroarylpiperidine and piperazine derivatives as fungicides | 拜耳知识产权有限责任公司 | 2020-10-27 | — | — | CN | disclosed |
| US-10426169-B2 | Heteroarylpiperidine and -piperazine derivatives as fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
| US-10246420-B2 | Pyrazole derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| EP-2921485-B1 | ISOXAZOLE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-07-18 | — | — | EP | disclosed |
| EP-2921484-B1 | OXAZOLE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-07-18 | — | — | EP | disclosed |
| US-8524743-B2 | Bis(difluoromethyl)pyrazoles as fungicides | BAYER CROPSCIENCE AG (DE) | 2013-09-03 | — | — | US | disclosed |
| WO-2013098229-A2 | HETEROARYLPIPERIDINE AND PIPERAZINE DERIVATIVES AS FUNGICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | WO | disclosed |
| EP-2516426-A1 | BIS(DIFLUORMETHYL)PYRAZOLES USED AS FUNGICIDES | Bayer CropScience AG (DE) | 2012-10-31 | — | — | EP | disclosed |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-09-15 | — | — | US | disclosed |
| WO-2011076699-A1 | BIS(DIFLUORMETHYL)PYRAZOLES USED AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044154-A1 | HETEROARYL PIPERIDINE AND HETEROARYL PIPERAZINE DERIVATIVES AS FUNGICIDES | PRXL2A, CYP1A1, CAT | TSHR 3091/4885GAA 504/4885HTR2C 1238/4885 |
| US-20170044153-A1 | HETEROARYL PIPERIDINE AND HETEROARYL PIPERAZINE DERIVATIVES AS FUNGICIDES | PRXL2A, CYP1A1, CAT | TSHR 3091/4885GAA 504/4885HTR2C 1238/4885 |
| US-10426169-B2 | Heteroarylpiperidine and -piperazine derivatives as fungicides | RB1, RBX1, RRP12 | TSHR 2139/4885GAA 1717/4885HTR2C 1859/4885 |
| US-10246420-B2 | Pyrazole derivatives | PDK3, PIR, CAT | TSHR 4032/4885GAA 1321/4885HTR2C 3782/4885 |
| US-20110224257-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | TSHR 3120/4885GAA 438/4885HTR2C 4327/4885 |
| US-20140057945-A1 | Bis(difluoromethyl)pyrazoles as Fungicides | CYP1A1, CYP4X1, CYP2F1 | TSHR 3120/4885GAA 438/4885HTR2C 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.