SCHEMBL19909231

SCHEMBL19909231

Cc1cc(-c2cc(-n3c4cc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)ccc4c4ccc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)cc43)c(C#N)c(-n3c4cc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)ccc4c4ccc(-c5cc(C(F)(F)F)cc(C(F)(F)F)c5)cc43)c2)cc(C)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.40
RXRA P19793 3/20 0.34
RXRB P28702 2/20 0.34
CTSS P25774 2/20 0.33
CTSK P43235 1/20 0.33
PSEN1 P49768 3/20 0.33
PSEN2 P49810 3/20 0.33
APH1B Q8WW43 3/20 0.33
NCSTN Q92542 3/20 0.33
APH1A Q96BI3 3/20 0.33
PSENEN Q9NZ42 3/20 0.33
RXRG P48443 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GRM2 Q14416 1/20 0.32
KDM4E B2RXH2 1/20 0.32
CYP11B2 P19099 2/20 0.32
CYP11B1 P15538 1/20 0.32
GRM5 P41594 2/20 0.31
NAAA Q02083 1/20 0.31
POLB P06746 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19919561 0.95 METAP2 (0.37) METAP2RXRARXRBCTSSCTSK
SCHEMBL19919562 0.95 METAP2 (0.37) METAP2RXRARXRBCTSSCTSK
SCHEMBL23487684 0.92 METAP2 (0.34) METAP2RXRARXRBCTSSCTSK
SCHEMBL19909225 0.91 CTSS (0.37) METAP2CTSSCTSKKDM4EGRM5
SCHEMBL19909230 0.91 RXRA (0.34) METAP2RXRARXRBCTSSCTSK
SCHEMBL19918047 0.91 RXRA (0.38) RXRARXRBCTSSCTSKRXRG
SCHEMBL19913315 0.90 METAP2 (0.36) METAP2RXRARXRBRXRGCYP11B2
SCHEMBL22170314 0.90 KIF11 (0.38) METAP2L3MBTL1KDM4ECYP11B2GRM5
SCHEMBL19917797 0.88 AR (0.42) RXRARXRBRXRGKDM4ECYP11B2
SCHEMBL19917808 0.88 KDM5B (0.35) RXRARXRBCTSSCTSKRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11588114-B2 Organic molecules for use in optoelectronic devices SAMSUNG DISPLAY CO., LTD. (KR) 2023-02-21 US disclosed
US-20200212316-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-07-02 US disclosed
EP-3287451-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-02-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200212316-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES OR10J3, OPRM1, OR51E2 METAP2 2365/4885RXRA 2792/4885RXRB 2162/4885
US-11588114-B2 Organic molecules for use in optoelectronic devices OR10J3, OPRM1, OR51E2 METAP2 2365/4885RXRA 2792/4885RXRB 2162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.