Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21574286 | 0.82 | KMT2A (0.49) | KMT2AMEN1KDM4EBCHEACHE | |
| SCHEMBL16709794 | 0.80 | ALDH1A1 (0.54) | KMT2AMEN1KDM4ERAB9APKM | |
| SCHEMBL13614141 | 0.77 | TERT (0.55) | KMT2AMEN1RAB9AMAPK1ALDH1A1 | |
| SCHEMBL4008452 | 0.73 | MAPT (0.62) | KMT2AMEN1KDM4ERAB9ANPC1 | |
| SCHEMBL19328847 | 0.73 | KDM4E (0.54) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2702564 | 0.72 | RAB9A (0.63) | KMT2AMEN1RAB9AMAPK1NPC1 | |
| SCHEMBL5199262 | 0.72 | MAOB (0.47) | KMT2AMEN1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5199245 | 0.72 | POLB (0.46) | KMT2AMEN1RAB9APKMALDH1A1 | |
| SCHEMBL2268420 | 0.72 | RAB9A (0.60) | KMT2AMEN1KDM4ERAB9APKM | |
| SCHEMBL4010777 | 0.72 | TSHR (0.54) | KMT2AMEN1KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065738-B1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |