Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910360 | 0.82 | KMT2A (0.52) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL18254566 | 0.81 | KMT2A (0.51) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL19328847 | 0.73 | KDM4E (0.54) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL21574212 | 0.73 | KDM4E (0.43) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL16702802 | 0.70 | KMT2A (0.53) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL18198052 | 0.69 | MPO (0.50) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL9903749 | 0.69 | SCN3A (0.63) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29953440 | 0.68 | RAB9A (0.52) | ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL16709794 | 0.68 | ALDH1A1 (0.54) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL4436999 | 0.67 | PDK1 (0.44) | KMT2AMEN1KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |