SCHEMBL19923623

SCHEMBL19923623

C[Si](C)(C)N1C(=O)CN(c2ccccc2)C1=O

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
CTSG P08311 14/20 0.47
CMA1 P23946 13/20 0.47
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
USP2 O75604 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
HPGD P15428 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19923732 0.81 CTSG (0.46) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL19923512 0.80 NPC1 (0.47) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL19923544 0.80 CTSG (0.44) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL2536250 0.75 NPC1 (0.54) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL19923534 0.73 ENPP2 (0.49) MEN1KMT2ACTSGCMA1MAPT
SCHEMBL9834330 0.73 KMT2A (0.61) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL151557 0.72 MEN1 (0.56) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL6363201 0.71 NPC1 (0.67) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL992528 0.71 MEN1 (0.54) NPC1RAB9AMEN1KMT2ACTSG
SCHEMBL7555141 0.71 NPC1 (0.54) NPC1RAB9AMEN1KMT2ACTSG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds BRIDGESTONE CORPORATION (JP) 2021-01-26 US claimed
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS BRIDGESTONE CORPORATION (JP) 2018-03-08 US claimed
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds BRIDGESTONE CORPORATION (JP) 2021-01-26 US disclosed
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS BRIDGESTONE CORPORATION (JP) 2018-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180065935-A1 POLYMERS FUNCTIONALIZED WITH N-PROTECTED HYDANTOIN COMPOUNDS PARG, HNMT, PARN NPC1 2048/4885RAB9A 2272/4885MEN1 2213/4885
US-10899718-B2 Polymers functionalized with N-protected hydantoin compounds HNMT, PARG, PAM NPC1 2239/4885RAB9A 2259/4885MEN1 2164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.