Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992434 | 1.00 | GSK3B (0.48) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| SCHEMBL1997107 | 0.83 | HDAC11 (0.41) | GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4556640 | 0.80 | CHRNA7 (0.34) | GAAKMT2ASMN1; SMN2 | |
| SCHEMBL1990957 | 0.80 | GSK3B (0.52) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| SCHEMBL1990956 | 0.80 | GSK3B (0.52) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| Maleic Acid SCHEMBL1988834 | 0.75 | GSK3B (0.46) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| Fumaric Acid SCHEMBL1988836 | 0.75 | GSK3B (0.46) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| Maleic Acid SCHEMBL1988832 | 0.75 | GSK3B (0.46) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 | |
| SCHEMBL1990714 | 0.75 | ALDH1A1 (0.40) | PIK3CAGAACISD1MEN1MAPT | |
| SCHEMBL6795136 | 0.71 | DYRK1A (0.79) | GSK3BCLK1DYRK1ADYRK1BCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263587-B2 | Benzoxazepine compounds, their preparation and use | PIRAMAL HEALTHCARE LIMITED (IN) | 2012-09-11 | — | — | US | claimed |
| EP-2077846-B1 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | PIRAMAL LIFE SCIENCES LTD (IN) | 2011-10-12 | — | — | EP | claimed |
| US-20110152247-A1 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | Piramal Enterprises Limited (IN) | 2011-06-23 | — | — | US | claimed |
| US-8263587-B2 | Benzoxazepine compounds, their preparation and use | PIRAMAL HEALTHCARE LIMITED (IN) | 2012-09-11 | — | — | US | disclosed |
| EP-2077846-B1 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | PIRAMAL LIFE SCIENCES LTD (IN) | 2011-10-12 | — | — | EP | disclosed |
| US-20110152247-A1 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | Piramal Enterprises Limited (IN) | 2011-06-23 | — | — | US | disclosed |
| EP-2077846-A2 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | Piramal Life Sciences Limited (IN) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008053446-A2 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152247-A1 | BENZOXAZEPINE COMPOUNDS, THEIR PREPARATION AND USE | GPR119, INSR, SLC5A1 | GSK3B 885/4885CLK1 2444/4885DYRK1A 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.