Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20058313 | 0.75 | LMNA (0.51) | P2RX4TDP1SMN1; SMN2CYP19A1L3MBTL1 | |
| SCHEMBL142480 | 0.68 | LPL (0.62) | MGLLL3MBTL1CA2 | |
| SCHEMBL22138689 | 0.68 | TDP1 (0.56) | TDP1SMN1; SMN2MGLLL3MBTL1 | |
| SCHEMBL17260672 | 0.68 | CASP3 (0.59) | HDAC1CA12CA1CA2CA9 | |
| Ethylene SCHEMBL27257282 | 0.67 | TP53 (0.52) | TDP1SMN1; SMN2 | |
| SCHEMBL6546791 | 0.67 | MAOA (0.56) | TDP1SMN1; SMN2 | |
| SCHEMBL18536709 | 0.67 | TDP1 (0.55) | TDP1SMN1; SMN2MGLLL3MBTL1MAPK1 | |
| SCHEMBL20853230 | 0.66 | PPARG (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Benzene SCHEMBL28308118 | 0.66 | TP53 (0.58) | TDP1SMN1; SMN2 | |
| Benzene SCHEMBL3223041 | 0.66 | TP53 (0.58) | TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018042342-A1 | 1,2,3-BENZOTRIAZOLE DERIVATIVES AS ROR GAMMA T MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-03-08 | — | — | WO | disclosed |