Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.47 |
| ▸ | KIT | P10721 | 10/20 | 0.47 |
| ▸ | SRC | P12931 | 10/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19943434 | 0.89 | LCK (0.53) | LCKKITSRCKDRJAK3 | |
| SCHEMBL21153647 | 0.87 | FGFR4 (0.54) | LCKKITSRCKDRJAK3 | |
| SCHEMBL19943152 | 0.86 | KDM4E (0.47) | FGFR4 | |
| SCHEMBL21153337 | 0.83 | FGFR4 (0.57) | LCKKITSRCKDRJAK3 | |
| SCHEMBL16676911 | 0.78 | FGFR4 (0.66) | LCKKITSRCKDRJAK3 | |
| SCHEMBL5489026 | 0.77 | LCK (0.55) | LCKKITSRCKDRJAK3 | |
| SCHEMBL22781316 | 0.76 | FGFR4 (0.52) | LCKKITSRCFGFR4 | |
| SCHEMBL22781190 | 0.75 | FGFR4 (0.56) | LCKKITSRCFGFR4 | |
| SCHEMBL21154011 | 0.74 | FGFR4 (0.55) | FGFR4 | |
| SCHEMBL21154059 | 0.74 | FGFR4 (0.56) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |