Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953173 | 0.82 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL19952995 | 0.81 | HCAR1 (0.40) | PTGS2PTGS1GABRG2GABRB3GABRA5 | |
| SCHEMBL19953169 | 0.75 | CYP3A4 (0.43) | EGLN2TRPM5PDE2APDE10A | |
| SCHEMBL1073380 | 0.72 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL19953095 | 0.68 | PDE4B (0.38) | EGLN2TRPM5PDE2APDE10A | |
| SCHEMBL19953199 | 0.68 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL19953048 | 0.68 | PTGS2 (0.42) | PTGS2PTGS1GABRG2GABRB3GABRA5 | |
| SCHEMBL1074163 | 0.68 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL15638551 | 0.66 | MAP3K14 (0.42) | FGFR1 | |
| SCHEMBL1074104 | 0.66 | PTGS2 (0.47) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |