Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960571 | 0.79 | GRM7 (0.39) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL8705275 | 0.66 | KMT2A (0.47) | OPRM1OPRK1OPRL1BRD4CREBBP | |
| SCHEMBL8704499 | 0.63 | OPRM1 (0.39) | OPRM1OPRK1OPRL1BRD4CREBBP | |
| SCHEMBL547428 | 0.63 | MEN1 (0.44) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL14104811 | 0.63 | MEN1 (0.38) | OPRM1ALDH1A1NOTUMMEN1KMT2A | |
| SCHEMBL8462462 | 0.63 | KDM4E (0.42) | ALDH1A1NOTUMMEN1KMT2APOLB | |
| SCHEMBL15609020 | 0.62 | SIGMAR1 (0.43) | ALDH1A1MEN1KMT2A | |
| SCHEMBL22744702 | 0.62 | HTT (0.44) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL30972513 | 0.62 | MAPT (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL1206839 | 0.61 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |