SCHEMBL19954465

SCHEMBL19954465

CNC(=O)c1ccc2nc(C(N)=O)[nH]c2c1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHEK2 O96017 10/20 0.52
PLK1 P53350 1/20 0.47
PLAU P00749 1/20 0.47
PKN1 Q16512 1/20 0.46
PKN2 Q16513 1/20 0.46
HSP90AA1 P07900 1/20 0.46
ESR2 Q92731 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
PIN1 Q13526 1/20 0.46
NPY5R Q15761 1/20 0.45
RET P07949 1/20 0.45
HDAC6 Q9UBN7 2/20 0.44
HDAC3 O15379 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28845532 0.82 HSP90AA1 (0.62) CHEK2PKN1PKN2HSP90AA1ESR2
SCHEMBL12430882 0.81 HSP90AA1 (0.69) CHEK2PLK1HSP90AA1ESR2TDP1
SCHEMBL9304604 0.79 CHEK2 (0.54) CHEK2PLK1HSP90AA1ESR2TDP1
SCHEMBL11211769 0.77 PIN1 (0.73) CHEK2PIN1
SCHEMBL14336559 0.77 ALDH1A1 (0.54) CHEK2PLK1HSP90AA1ESR2TDP1
SCHEMBL17693449 0.74 PIN1 (0.47) CHEK2PKN1PKN2PIN1
SCHEMBL7152026 0.74 HTR3E (0.57) CHEK2TDP1
SCHEMBL7153789 0.74 EGLN1 (0.62) CHEK2
SCHEMBL19094535 0.72 SMYD3 (0.62) CHEK2PLK1TDP1NPY5RRET
SCHEMBL30732472 0.72 CHEK2 (0.47) CHEK2PKN1PKN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9916931-B2 Energy storage devices and methods of production thereof CAPACITOR SCIENCE INCORPORATED (US) 2018-03-13 US disclosed