Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22560184 | 0.93 | TGFBR1 (0.38) | NR3C2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19954631 | 0.86 | TGFBR1 (0.43) | NR3C2TGFBR1PDE10ALRRK2 | |
| SCHEMBL25745871 | 0.85 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14TRPV1 | |
| SCHEMBL24815018 | 0.83 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14TRPV1 | |
| SCHEMBL19954641 | 0.83 | NR3C1 (0.35) | NR3C2TGFBR1HRH3 | |
| SCHEMBL19954623 | 0.83 | CYP1A2 (0.32) | TGFBR1LRRK2 | |
| SCHEMBL15069885 | 0.81 | MAPK13 (0.40) | MAPK13MAPK12MAPK11MAPK14LRRK2 | |
| SCHEMBL25745875 | 0.81 | MAPK13 (0.44) | NR3C2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18164107 | 0.80 | GAA (0.41) | NR3C2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19954603 | 0.80 | TRPV4 (0.43) | NR3C2TGFBR1GAAKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914706-B2 | N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-13 | — | — | US | disclosed |