Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16805973 | 0.85 | NR3C1 (0.41) | TRPV4IRAK4NR3C1MAPK1ALDH1A1 | |
| SCHEMBL19953971 | 0.83 | TRPV4 (0.41) | TRPV4NR3C1MAPK1ALDH1A1HPGD | |
| SCHEMBL22560184 | 0.82 | TGFBR1 (0.38) | TRPV4LMNAGAATGFBR1NR3C2 | |
| SCHEMBL19954664 | 0.81 | MAPK1 (0.39) | TRPV4IRAK4NR3C1MAPK1ALDH1A1 | |
| SCHEMBL24813393 | 0.81 | MAPK13 (0.33) | TRPV4DRD2DRD4DRD3 | |
| SCHEMBL19954636 | 0.80 | NR3C2 (0.39) | ALDH1A1GAATGFBR1HSD17B10KCNH2 | |
| SCHEMBL25745883 | 0.79 | DRD2 (0.39) | ALDH1A1DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL19954641 | 0.78 | NR3C1 (0.35) | NR3C1TGFBR1NR3C2 | |
| SCHEMBL18164008 | 0.78 | GAA (0.38) | TRPV4IRAK4NR3C1MAPK1LMNA | |
| SCHEMBL19954631 | 0.76 | TGFBR1 (0.43) | IRAK4TGFBR1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914706-B2 | N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-13 | — | — | US | disclosed |