Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968027 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HTTCLK1DYRK1A | |
| SCHEMBL19646227 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP3A4CYP2D6KCNH2SLC6A2 | |
| SCHEMBL18427396 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP3A4CYP2D6KCNH2SLC6A2 | |
| SCHEMBL26399905 | 0.84 | KCNH2 (0.31) | SMN1; SMN2CYP3A4CYP2D6KCNH2SLC6A2 | |
| SCHEMBL22374288 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HTTCLK1DYRK1A | |
| SCHEMBL21653566 | 0.81 | SMN1; SMN2 (0.33) | SMN1; SMN2CYP3A4CYP2D6KCNH2SLC6A2 | |
| SCHEMBL21451766 | 0.79 | BACE1 (0.35) | SMN1; SMN2CYP3A4CYP2D6KCNH2SLC6A2 | |
| SCHEMBL22166482 | 0.79 | RXRA (0.34) | SMN1; SMN2ALDH1A1HTTCYP3A4CYP2D6 | |
| SCHEMBL29296781 | 0.78 | LMNA (0.33) | SMN1; SMN2KCNH2L3MBTL1LMNAKDM4E | |
| SCHEMBL24397435 | 0.77 | NAMPT (0.38) | SMN1; SMN2NAMPTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000843-A1 | MEDICINAL COGNITIVE TREATMENTS | Actinogen Medical Limited (AU) | 2023-01-05 | — | — | US | disclosed |
| US-11241450-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | TUFTS UNIVERSITY (US) | 2022-02-08 | — | — | US | disclosed |
| US-11124536-B2 | Uridine nucleoside derivatives, compositions and methods of use | TUFTS UNIVERSITY (US) | 2021-09-21 | — | — | US | disclosed |
| US-20210221803-A1 | ATF6 INHIBITORS AND USES THEREOF | ALTOS LABS, INC. | 2021-07-22 | — | — | US | disclosed |
| US-20210069226-A1 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF | TUFTS UNIVERSITY (US) | 2021-03-11 | — | — | US | disclosed |
| US-20200399302-A1 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | TUFTS UNIVERSITY | 2020-12-24 | — | — | US | disclosed |
| US-10829485-B2 | ATF6 inhibitors and uses thereof | BLACK BELT TX LTD (GB) | 2020-11-10 | — | — | US | disclosed |
| US-10632138-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | TUFTS UNIVERSITY (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | TUFTS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
| US-9913855-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | TUFTS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124536-B2 | Uridine nucleoside derivatives, compositions and methods of use | P2RY6, UPP1, UMPS | SMN1; SMN2 278/4885ALDH1A1 2982/4885HTT 818/4885 |
| US-20200399302-A1 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | P2RY6, UPP1, UMPS | SMN1; SMN2 278/4885ALDH1A1 2982/4885HTT 818/4885 |
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | P2RY6, UPP1, UMPS | SMN1; SMN2 410/4885ALDH1A1 3211/4885HTT 872/4885 |
| US-20230000843-A1 | MEDICINAL COGNITIVE TREATMENTS | PYGB, CHAT, COMT | SMN1; SMN2 270/4885ALDH1A1 1344/4885HTT 311/4885 |
| US-10829485-B2 | ATF6 inhibitors and uses thereof | ATF4, XBP1, ATF1 | SMN1; SMN2 1522/4885ALDH1A1 4447/4885HTT 713/4885 |
| US-20210221803-A1 | ATF6 INHIBITORS AND USES THEREOF | ATF4, XBP1, ATF1 | SMN1; SMN2 1522/4885ALDH1A1 4447/4885HTT 713/4885 |
| US-20210069226-A1 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND USES THEREOF | UMPS, UPP1, UGDH | SMN1; SMN2 789/4885ALDH1A1 1514/4885HTT 701/4885 |
| US-11241450-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | UMPS, UPP1, UGDH | SMN1; SMN2 789/4885ALDH1A1 1514/4885HTT 701/4885 |
| US-10632138-B2 | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof | UMPS, UPP1, UGDH | SMN1; SMN2 789/4885ALDH1A1 1514/4885HTT 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.