Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940835 | 0.83 | ALDH1A1 (0.37) | SIGMAR1 | |
| SCHEMBL19916510 | 0.81 | — | — | |
| SCHEMBL23812243 | 0.80 | MEN1 (0.40) | POLBSMN1; SMN2SIGMAR1CXCR4HSD17B10 | |
| SCHEMBL3888868 | 0.77 | ADRB1 (0.33) | SIGMAR1 | |
| SCHEMBL104919 | 0.77 | ADRB1 (0.33) | SIGMAR1 | |
| SCHEMBL24778035 | 0.76 | — | — | |
| SCHEMBL20314540 | 0.76 | PDE4A (0.37) | POLBSMN1; SMN2SIGMAR1CXCR4 | |
| SCHEMBL18681961 | 0.76 | GNAO1 (0.36) | — | |
| SCHEMBL16202946 | 0.76 | ACHE (0.32) | SIGMAR1 | |
| SCHEMBL24309004 | 0.75 | LTA4H (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914723-B2 | Small molecule inhibitors of Mcl-1 and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-03-13 | — | — | US | disclosed |