Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | PYGM | P11217 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953601 | 0.81 | NPY5R (0.35) | KMT2ATSHRMEN1MC4R | |
| SCHEMBL19960817 | 0.78 | GRIA1 (0.34) | KMT2ATSHRMEN1 | |
| SCHEMBL19960879 | 0.77 | MEN1 (0.42) | GRM7PYGLPYGMFABP5EPHX2 | |
| SCHEMBL19953484 | 0.73 | GRM7 (0.43) | GRM7PYGLPYGMPOLBFABP5 | |
| SCHEMBL19960818 | 0.73 | PER2 (0.33) | KMT2AMEN1 | |
| SCHEMBL19960700 | 0.69 | GRM7 (0.43) | GRM7PYGLPYGMPOLBFABP5 | |
| SCHEMBL19953525 | 0.68 | ALDH1A1 (0.44) | GRM7FABP5KMT2ACHRNA7MEN1 | |
| SCHEMBL19953514 | 0.68 | OPRM1 (0.43) | FABP5EPHX2TSHRHRH3MTNR1A | |
| SCHEMBL19960593 | 0.67 | FABP5 (0.43) | GRM7PYGLPYGMFABP5EPHX2 | |
| SCHEMBL19960567 | 0.66 | GRM7 (0.42) | GRM7PAX8POLBFABP5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |