Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19965013 | 0.92 | CYP11B2 (0.43) | PRKCAPRKCEMAP3K5ROCK2CYP19A1 | |
| SCHEMBL19965197 | 0.86 | CYP11B2 (0.54) | MAP3K5NPC1RAB9APKMCYP11B2 | |
| SCHEMBL19965120 | 0.80 | SMN1; SMN2 (0.46) | MAP3K5GRM4NPC1RAB9ACYP11B2 | |
| SCHEMBL19965003 | 0.80 | CYP11B2 (0.38) | MAP3K5ADAM17CYP11B2 | |
| SCHEMBL19965112 | 0.78 | FFAR4 (0.36) | MAP3K5MAPK1CYP11B2 | |
| SCHEMBL13113488 | 0.73 | PRKCA (0.47) | PRKCAPRKCEMAP3K5ADAM17GRM4 | |
| SCHEMBL13113490 | 0.72 | ADAM17 (0.44) | PRKCAPRKCEMAP3K5ADAM17TNF | |
| SCHEMBL13113259 | 0.72 | MEN1 (0.48) | PRKCAPRKCEMAP3K5ADAM17GRM4 | |
| SCHEMBL19965052 | 0.71 | CYP11B2 (0.56) | MAP3K5NPC1RAB9APKMCYP11B2 | |
| SCHEMBL19965105 | 0.71 | HRH4 (0.42) | ROCK2CYP19A1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183231-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | Valo Health, LLC | 2023-06-15 | — | — | US | disclosed |
| US-20230183231-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | Valo Health, LLC | 2023-06-15 | — | — | US | disclosed |
| US-11548886-B2 | Monocyclic compounds useful as GPR120 modulators | VALO HEALTH, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210101896-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | Valo Health, LLC | 2021-04-08 | — | — | US | disclosed |
| US-10800773-B2 | Monocyclic compounds useful as GPR120 modulators | INTEGRAL HEALTH, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| US-20190202821-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | Valo Health, LLC | 2019-07-04 | — | — | US | disclosed |
| WO-2018049324-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | NUMERATE, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548886-B2 | Monocyclic compounds useful as GPR120 modulators | GPR119, GPR180, GPR65 | PRKCA 771/4885PRKCE 583/4885MAP3K5 2081/4885 |
| US-10800773-B2 | Monocyclic compounds useful as GPR120 modulators | GPR119, GPR180, GPR65 | PRKCA 771/4885PRKCE 583/4885MAP3K5 2081/4885 |
| US-20210101896-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | GPR119, GPR180, GPR65 | PRKCA 771/4885PRKCE 583/4885MAP3K5 2081/4885 |
| US-20190202821-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | GPR119, GPR180, GPR65 | PRKCA 771/4885PRKCE 583/4885MAP3K5 2081/4885 |
| US-20230183231-A1 | MONOCYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | GPR119, GPR180, GPR65 | PRKCA 771/4885PRKCE 583/4885MAP3K5 2081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.