Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 2/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21273276 | 0.88 | GPR119 (0.46) | GPR119SMN1; SMN2MAPT | |
| SCHEMBL19975223 | 0.81 | GPR119 (0.34) | GPR119OGAHTTSMN1; SMN2MLYCD | |
| SCHEMBL21381142 | 0.79 | HRH3 (0.38) | OGAHTTSMN1; SMN2MLYCDCCR5 | |
| SCHEMBL19975384 | 0.78 | MLYCD (0.38) | OGAHTTSMN1; SMN2MLYCDCCR5 | |
| SCHEMBL12810893 | 0.78 | CCR5 (0.36) | OGAHTTSMN1; SMN2MLYCDCCR5 | |
| SCHEMBL12810894 | 0.78 | ALDH1A1 (0.47) | OGAHTTSMN1; SMN2CCR5LMNA | |
| SCHEMBL19975474 | 0.76 | LMNA (0.31) | LMNARAB9APOLBL3MBTL1 | |
| SCHEMBL21273298 | 0.75 | PDE10A (0.32) | LMNARAB9APOLBL3MBTL1 | |
| SCHEMBL12440439 | 0.73 | GPR119 (0.45) | GPR119SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL19975015 | 0.72 | GPR119 (0.46) | GPR119SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512845-A1 | HEPATITIS B CORE PROTEIN MODULATORS | Assembly Biosciences, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |