Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21273290 | 0.86 | GPR119 (0.50) | GPR119MAPT | |
| SCHEMBL19975482 | 0.81 | GPR119 (0.34) | GPR119OGAHTTSMN1; SMN2LMNA | |
| SCHEMBL21381142 | 0.80 | HRH3 (0.38) | OGAHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL19975384 | 0.79 | MLYCD (0.38) | OGAHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL12810893 | 0.79 | CCR5 (0.36) | OGAHTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL12810894 | 0.79 | ALDH1A1 (0.47) | OGAHTTSMN1; SMN2LMNACCR5 | |
| SCHEMBL19984507 | 0.76 | — | — | |
| SCHEMBL1577774 | 0.74 | TRPC6 (0.38) | GPR119HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL1557136 | 0.74 | GPR119 (0.38) | GPR119SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL19975036 | 0.73 | CCR5 (0.33) | OGAHTTSMN1; SMN2CCR5MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512845-A1 | HEPATITIS B CORE PROTEIN MODULATORS | Assembly Biosciences, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |