Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 12/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976909 | 0.93 | POLB (0.34) | LMNAHPGDPOLBMAPK1ALDH1A1 | |
| SCHEMBL19976777 | 0.82 | POLB (0.39) | LMNAHPGDPOLBMAPK1DGAT2 | |
| SCHEMBL19976784 | 0.82 | MAPK1 (0.38) | POLBMAPK1DGAT2 | |
| SCHEMBL19976740 | 0.81 | HPGD (0.39) | LMNAHPGDPOLBMAPK1DGAT2 | |
| SCHEMBL19976880 | 0.80 | PDE10A (0.36) | LMNAHPGDPOLBMAPK1 | |
| SCHEMBL19362794 | 0.80 | RAB9A (0.47) | LMNAKDM4EALDH1A1GAA | |
| SCHEMBL19976851 | 0.79 | POLB (0.35) | LMNAHPGDPOLBMAPK1KDM4E | |
| SCHEMBL19976944 | 0.79 | MAPK1 (0.36) | LMNAHPGDPOLBMAPK1KDM4E | |
| SCHEMBL19976739 | 0.78 | HPGD (0.37) | LMNAHPGDPOLBMAPK1ALDH1A1 | |
| SCHEMBL18558416 | 0.78 | RAB9A (0.37) | LMNAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |