Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.42 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976958 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2P2RX7KDRNPC1RAB9A | |
| SCHEMBL16993947 | 0.83 | KMT2A (0.53) | GPR139RAB9AKMT2AHDAC1 | |
| SCHEMBL19976980 | 0.81 | NPC1 (0.66) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL19977039 | 0.81 | KDR (0.70) | SMN1; SMN2KDRNPC1RAB9AMAPT | |
| SCHEMBL19976894 | 0.80 | ALDH1A1 (0.62) | SMN1; SMN2MAPTKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL19977038 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL19976970 | 0.77 | NPC1 (0.53) | SMN1; SMN2GPR139NPC1RAB9AMAPT | |
| SCHEMBL19976922 | 0.76 | HPGD (0.66) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL1725253 | 0.75 | ALDH1A1 (0.49) | SMN1; SMN2NPC1RAB9AP2RY1MAPT | |
| SCHEMBL19977124 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9919998-B2 | Antibacterial agents: Nα-aroyl-N-aryl-phenylalaninamides | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-03-20 | — | — | US | disclosed |