Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22710190 | 0.79 | ROCK2 (0.48) | ERN1 | |
| SCHEMBL23081625 | 0.78 | ERN1 (0.46) | ERN1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19655565 | 0.76 | ALDH1A1 (0.42) | CYP1A2CYP2C9CYP2C19NPC1RAB9A | |
| SCHEMBL30195973 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL23189282 | 0.74 | HPGD (0.38) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL19980436 | 0.74 | HTR2C (0.41) | CYP19A1KDM4EGAAMAPTHPGD | |
| SCHEMBL22048701 | 0.74 | KMT2A (0.47) | CYP1A2CYP2D6CYP2C19NPC1RAB9A | |
| SCHEMBL19980139 | 0.74 | CSNK2A1 (0.40) | CYP1A2CYP2D6CYP19A1CYP2C19SMN1; SMN2 | |
| SCHEMBL19980257 | 0.74 | HTR1D (0.41) | CYP1A2CYP2D6SMN1; SMN2KDM4EMAPT | |
| SCHEMBL19980507 | 0.74 | ACHE (0.53) | NPC1RAB9ASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |