Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RRM2 | P31350 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487033 | 0.83 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CMAPTNOS3 | |
| SCHEMBL20929322 | 0.82 | MAPT (0.42) | ADRA2AADRA2BADRA2CMAPTNOS3 | |
| SCHEMBL5694416 | 0.82 | MAOA (0.43) | MAPTNOS3NOS2GAANAMPT | |
| SCHEMBL12102026 | 0.80 | MAPT (0.46) | ADRA2AADRA2BADRA2CMAPTGAA | |
| SCHEMBL22175094 | 0.78 | MAPT (0.38) | ADRA2AADRA2BADRA2CMAPTNOS3 | |
| SCHEMBL18779716 | 0.77 | KCNH3 (0.40) | ADRA2AADRA2BADRA2CNOS3NOS2 | |
| SCHEMBL28820864 | 0.76 | NOS3 (0.42) | ADRA2AADRA2BADRA2CMAPTNOS3 | |
| SCHEMBL16963191 | 0.76 | HRH3 (0.47) | NOS3NOS2GAA | |
| SCHEMBL2483964 | 0.76 | KCNH3 (0.48) | MAPTNOS3NOS2GAAALPL | |
| SCHEMBL20878669 | 0.76 | MTNR1A (0.48) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |