Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982244 | 0.91 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL8189803 | 0.79 | KMT2A (0.58) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL19974578 | 0.78 | ALDH1A1 (0.55) | ALDH1A1POLBACEACE2 | |
| SCHEMBL22929115 | 0.77 | ITGB1 (0.46) | ALDH1A1KDM4EPOLBACEACE2 | |
| SCHEMBL19982124 | 0.76 | CYP3A4 (0.53) | ALDH1A1KDM4EPOLBGAAL3MBTL1 | |
| SCHEMBL8190070 | 0.76 | KMT2A (0.60) | LMNAKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL19982177 | 0.73 | YAP1 (0.60) | GAAL3MBTL1 | |
| SCHEMBL13700884 | 0.72 | ALDH1A1 (0.56) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL1302762 | 0.71 | SMN1; SMN2 (0.57) | LMNAKMT2AALDH1A1MEN1HTT | |
| SCHEMBL22929113 | 0.71 | ACE (0.46) | LMNAALDH1A1MAPTHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |