Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 5/20 | 0.43 |
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22929113 | 0.93 | ACE (0.46) | ITGB1ITGA4ALDH1A1STAT3PREP | |
| SCHEMBL19982124 | 0.88 | CYP3A4 (0.53) | ITGB1ITGA4ALDH1A1STAT3ACE | |
| SCHEMBL22929164 | 0.87 | ITGB1 (0.46) | ITGB1ITGA4PREPLTA4HACE | |
| SCHEMBL19974578 | 0.87 | ALDH1A1 (0.55) | ITGB1ITGA4ALDH1A1STAT3ACE | |
| SCHEMBL22929163 | 0.83 | ACE (0.47) | ITGB1ITGA4ALDH1A1ACEPOLB | |
| SCHEMBL19982125 | 0.81 | YAP1 (0.57) | ACE | |
| SCHEMBL22929165 | 0.80 | YAP1 (0.57) | ACE | |
| SCHEMBL19982123 | 0.80 | STAT3 (0.47) | ITGB1ITGA4ALDH1A1STAT3ACE | |
| SCHEMBL19982261 | 0.77 | LMNA (0.51) | ALDH1A1ACEPOLBKDM4EACE2 | |
| SCHEMBL9279601 | 0.76 | CTRB1 (0.51) | PREPLTA4HACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, IWS1, YES1 | ITGB1 4473/4885ITGA4 3842/4885ALDH1A1 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.