SCHEMBL19984087

SCHEMBL19984087

CNCc1cn(Sc2cccnc2)c2cc(Nc3c(Cl)cc(Cl)cc3Cl)ccc12

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
MAP3K8 P41279 5/20 0.33
HTR2C P28335 1/20 0.32
MAPK13 O15264 1/20 0.32
EIF2AK2 P19525 1/20 0.32
MAPK12 P53778 1/20 0.32
MAPK11 Q15759 1/20 0.32
MAPK14 Q16539 1/20 0.32
EGFR P00533 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19983733 0.89 SLC6A2 (0.37) SLC6A2SLC6A4HTR2C
SCHEMBL19983703 0.88 LCK (0.37)
SCHEMBL19983727 0.88 ABL1 (0.36) SLC6A2SLC6A4HTR2C
SCHEMBL19983883 0.87 HTR2C (0.32) SLC6A2SLC6A4HTR2CEGFR
SCHEMBL19983848 0.86 MAP3K8 (0.32) MAP3K8HTR2CMAPK13EIF2AK2MAPK12
SCHEMBL19984241 0.86 RAPGEF4 (0.32) HTR2C
SCHEMBL19984177 0.85 HTR2C (0.39) HTR2C
SCHEMBL19984199 0.85 MAP3K8 (0.31) MAP3K8HTR2CMAPK13EIF2AK2MAPK12
SCHEMBL19984127 0.84 NUDT1 (0.36) SLC6A2SLC6A4MAP3K8EGFR
SCHEMBL19984171 0.84 POLB (0.37) SLC6A2HTR2CMAPK14EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed