⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975474 | 0.79 | LMNA (0.31) | — | |
| SCHEMBL19975174 | 0.78 | SLC5A2 (0.33) | — | |
| SCHEMBL19975213 | 0.78 | IDO1 (0.31) | — | |
| SCHEMBL19975363 | 0.78 | IDO1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL19975373 | 0.77 | LOXL2 (0.31) | — | |
| SCHEMBL19975223 | 0.76 | GPR119 (0.34) | — | |
| SCHEMBL21273290 | 0.72 | GPR119 (0.50) | — | |
| SCHEMBL19975224 | 0.72 | — | — | |
| SCHEMBL9899996 | 0.70 | ALDH1A1 (0.34) | — | |
| SCHEMBL6625545 | 0.68 | SLC6A3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220023311-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2022-01-27 | — | — | US | disclosed |
| US-10987360-B2 | Hepatitis B core protein modulators | ASSEMBLY BIOSCIENCES, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-20190255067-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES INC (US) | 2019-08-22 | — | — | US | disclosed |
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |