Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984830 | 0.79 | LMNA (0.67) | LMNAPOLBKMT2AMEN1PKM | |
| SCHEMBL19984807 | 0.76 | TP53 (0.43) | LMNAKMT2ATHRBTP53SMN1; SMN2 | |
| SCHEMBL19984792 | 0.72 | KMT2A (0.41) | LMNAKMT2AMEN1THRBGUSB | |
| SCHEMBL19984803 | 0.71 | KMT2A (0.41) | LMNAKMT2AMEN1THRBGUSB | |
| SCHEMBL19984794 | 0.70 | KMT2A (0.41) | LMNAKMT2ATHRBTP53SMN1; SMN2 | |
| SCHEMBL19984787 | 0.68 | VDR (0.46) | LMNAKMT2AMEN1THRBGUSB | |
| SCHEMBL19984971 | 0.68 | ADAMTS4 (0.45) | LMNAKMT2AMEN1THRBGUSB | |
| SCHEMBL19984798 | 0.68 | CTSA (0.47) | LMNAKMT2AMEN1THRBTP53 | |
| SCHEMBL19984856 | 0.67 | CTSS (0.44) | LMNAPOLBKMT2AMEN1THRB | |
| SCHEMBL19984853 | 0.67 | CTSS (0.44) | LMNAPOLBKMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018051255-A1 | CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-22 | — | — | WO | disclosed |