SCHEMBL19985758

SCHEMBL19985758

CCCCc1ccc(Nc2ccc(O)c(C(C)(C)C)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
ALDH1A1 P00352 3/20 0.45
LMNA P02545 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
GAA P10253 2/20 0.45
MAPT P10636 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
MEN1 O00255 1/20 0.45
ALOX12 P18054 1/20 0.45
MAPK1 P28482 1/20 0.45
KMT2A Q03164 1/20 0.45
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
NR1H4 Q96RI1 1/20 0.41
POLB P06746 1/20 0.41
HSD17B10 Q99714 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL673963 0.83 HTT (0.52) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL29612324 0.83 HTT (0.52) HPGDNPC1RAB9AALDH1A1LMNA
Methane SCHEMBL27924017 0.82 HTT (0.50) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL8434182 0.81 ALDH1A1 (0.44) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL27685437 0.79 KAT8 (0.54) ALDH1A1LMNAHSD17B10HTTNR1I2
SCHEMBL19987328 0.78 ALDH1A1 (0.52) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL14127779 0.78 HPGD (0.58) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL48879 0.78 HPGD (0.58) HPGDNPC1RAB9AALDH1A1LMNA
SCHEMBL107937 0.77 KAT8 (0.56) ALDH1A1LMNAHSD17B10HTTNR1I2
SCHEMBL109409 0.77 KAT8 (0.56) ALDH1A1LMNAHSD17B10HTTNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3516019-B1 LUBRICANT COMPOSITIONS STABILIZED BY MIXTURES OF DIARYLAMINE AND HYDROXYDIARYLAMINE ANTIOXIDANTS LANXESS CORP (US) 2023-06-14 EP disclosed
EP-3516020-B1 ALKYLATED 3-HYDROXYDIPHENYLAMINE ANTIOXIDANTS LANXESS CORP (US) 2022-05-25 EP disclosed
US-10723969-B2 Lubricant compositions stabilized by mixtures of diarylamine and hydroxydiarylamine antioxidants LANXESS SOLUTIONS US INC. (US) 2020-07-28 US disclosed
US-10563145-B2 Alkylated 3-hydroxydiphenylamine antioxidants LANXESS SOLUTIONS US INC. (US) 2020-02-18 US disclosed
WO-2018057366-A1 ALKYLATED 3-HYDROXYDIPHENYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2018-03-29 WO disclosed
WO-2018057364-A1 LUBRICANT COMPOSITIONS STABILIZED BY MIXTURES OF DIARYLAMINE AND HYDROXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2018-03-29 WO disclosed
US-20180079985-A1 ALKYLATED 3-HYDROXYDIPHENYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. 2018-03-22 US disclosed
US-20180079987-A1 LUBRICANT COMPOSITIONS STABILIZED BY MIXTURES OF DIARYLAMINE AND HYDROXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. 2018-03-22 US disclosed
US-20180079985-A1 ALKYLATED 3-HYDROXYDIPHENYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. 2018-03-22 US disclosed
US-20180079987-A1 LUBRICANT COMPOSITIONS STABILIZED BY MIXTURES OF DIARYLAMINE AND HYDROXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. 2018-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180079985-A1 ALKYLATED 3-HYDROXYDIPHENYLAMINE ANTIOXIDANTS GPX4, GSTO1, LPO HPGD 97/4885NPC1 661/4885RAB9A 4561/4885
US-10563145-B2 Alkylated 3-hydroxydiphenylamine antioxidants GPX4, GSTO1, LPO HPGD 97/4885NPC1 661/4885RAB9A 4561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.