SCHEMBL19986718

SCHEMBL19986718

Cc1cc(NC(=O)NCCCNc2c(C)cncc2C)cc(C)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
MAPT P10636 2/20 0.42
CDK2 P24941 2/20 0.42
FLT4 P35916 1/20 0.42
EPHX2 P34913 1/20 0.40
KMT2A Q03164 2/20 0.38
SLC6A3 Q01959 1/20 0.38
QPCT Q16769 3/20 0.38
CHEK1 O14757 1/20 0.37
AURKA O14965 1/20 0.37
CHUK O15111 1/20 0.37
DAPK3 O43293 1/20 0.37
JAK2 O60674 1/20 0.37
ROCK2 O75116 1/20 0.37
PAK4 O96013 1/20 0.37
CHEK2 O96017 1/20 0.37
PRKCG P05129 1/20 0.37
CDK1 P06493 1/20 0.37
MET P08581 1/20 0.37
PIM1 P11309 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19986708 0.85 KDM4E (0.39) ALDH1A1MAPTCDK2FLT4EPHX2
SCHEMBL19986507 0.79 KMT2A (0.38) ALDH1A1MAPTCDK2FLT4EPHX2
SCHEMBL19986466 0.79 L3MBTL1 (0.36) KDM4ERAB9A
SCHEMBL19986554 0.77 MEN1 (0.47) ALDH1A1MAPTFLT4EPHX2KMT2A
SCHEMBL19986671 0.76 EPHX2 (0.49) ALDH1A1MAPTEPHX2KMT2ASLC6A3
SCHEMBL19986631 0.75 KMT2A (0.53) ALDH1A1MAPTKMT2ARAB9ANPC1
SCHEMBL19986712 0.75 MEN1 (0.47) ALDH1A1MAPTCDK2FLT4KMT2A
SCHEMBL19986714 0.75 ALOX15 (0.43) ALDH1A1CDK2FLT4EPHX2KMT2A
SCHEMBL19986564 0.74 NAMPT (0.52) ALDH1A1EPHX2KMT2ARAB9ANPC1
SCHEMBL19986446 0.74 KMT2A (0.49) ALDH1A1MAPTEPHX2KMT2ASLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018050110-A1 NOVEL CAPSID PROTEIN ASSEMBLY INHIBITOR 正大天晴药业集团股份有限公司 2018-03-22 WO disclosed