Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007882 | 0.94 | HSD17B10 (0.40) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL2003907 | 0.92 | L3MBTL1 (0.41) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2006836 | 0.91 | MCL1 (0.40) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2006280 | 0.90 | FAAH (0.44) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2007516 | 0.89 | S1PR3 (0.38) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2006664 | 0.88 | ALOX5AP (0.36) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2004791 | 0.88 | MAPT (0.44) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2006216 | 0.88 | ACHE (0.47) | MAPTPKMALDH1A1LMNAMEN1 | |
| SCHEMBL2004677 | 0.88 | MAPT (0.41) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2002167 | 0.87 | ALOX5AP (0.43) | MAPTLMNAALOX5APCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |