SCHEMBL2002167 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	ALOX5AP	P20292	13/20	0.43

▸	ALOX5	P09917	6/20	0.43

▸	CYP3A4	P08684	1/20	0.43

▸	CYP2C9	P11712	1/20	0.43

▸	PTGS1	P23219	1/20	0.39

▸	LMNA	P02545	1/20	0.39

▸	MAPT	P10636	1/20	0.39

▸	ACHE	P22303	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2006216	0.92	ACHE (0.47)	ALOX5APALOX5CYP3A4CYP2C9PTGS1
SCHEMBL2007246	0.92	LMNA (0.38)	ALOX5APALOX5CYP3A4CYP2C9PTGS1
SCHEMBL1999807	0.90	ALOX5AP (0.42)	ALOX5APALOX5CYP3A4CYP2C9PTGS1
SCHEMBL2007882	0.90	HSD17B10 (0.40)	ALOX5APALOX5CYP3A4CYP2C9LMNA
SCHEMBL2005411	0.89	ALOX5AP (0.42)	ALOX5APALOX5CYP3A4CYP2C9LMNA
SCHEMBL2004203	0.89	ALOX5AP (0.45)	ALOX5APALOX5CYP3A4CYP2C9
SCHEMBL2008229	0.89	ALOX5AP (0.40)	ALOX5APALOX5CYP3A4CYP2C9PTGS1
SCHEMBL2006280	0.88	FAAH (0.44)	ALOX5APALOX5CYP3A4CYP2C9PTGS1
SCHEMBL1999222	0.87	MAPT (0.40)	ALOX5APALOX5CYP3A4CYP2C9LMNA
SCHEMBL2000884	0.87	FAAH (0.44)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7960544-B2	Useful indole compounds	IRONWOOD PHARMACEUTICALS, INC. (US)	2011-06-14	—	—	US	disclosed