Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012906 | 0.93 | MAPT (0.44) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL2007363 | 0.91 | ALOX5AP (0.40) | MAPTALDH1A1GAAPKMKDM4E | |
| SCHEMBL2008306 | 0.91 | L3MBTL1 (0.43) | MAPTALDH1A1GAAPKMKDM4E | |
| SCHEMBL2003239 | 0.91 | PTGES2 (0.41) | MAPTALDH1A1GAAPKMKDM4E | |
| SCHEMBL2002616 | 0.90 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL2003126 | 0.90 | MEN1 (0.44) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL2005862 | 0.88 | MAPT (0.41) | MAPTALDH1A1GAAPKMKDM4E | |
| SCHEMBL1999222 | 0.88 | MAPT (0.40) | MAPTALDH1A1GAAPKMKDM4E | |
| SCHEMBL1999556 | 0.87 | PLA2G2A (0.49) | MAPTALDH1A1PKMLMNAMEN1 | |
| SCHEMBL2004203 | 0.86 | ALOX5AP (0.45) | ALDH1A1KDM4EALOX5APPLA2G2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |