Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999222 | 0.94 | MAPT (0.40) | CYP3A4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL2006836 | 0.93 | MCL1 (0.40) | CYP3A4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2006280 | 0.93 | FAAH (0.44) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL2000474 | 0.92 | LMNA (0.41) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL2006216 | 0.90 | ACHE (0.47) | CYP3A4MAPTMEN1KMT2ATSHR | |
| SCHEMBL2002167 | 0.90 | ALOX5AP (0.43) | CYP3A4MAPTALOX5APALOX5CYP2C9 | |
| SCHEMBL2009144 | 0.88 | CYP3A4 (0.38) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL2004901 | 0.88 | MAPT (0.36) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL2012906 | 0.87 | MAPT (0.44) | HSD17B10CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL2004385 | 0.87 | LMNA (0.43) | CYP3A4MAPTMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |