Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 16/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6796503 | 0.99 | OPRD1 (0.97) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL6796629 | 0.87 | OPRD1 (0.97) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL6791218 | 0.84 | OPRD1 (0.97) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL219432 | 0.82 | MEN1 (1.00) | OPRD1MEN1KMT2AOPRM1SLC6A4 | |
| SCHEMBL2794662 | 0.82 | MEN1 (1.00) | OPRD1MEN1KMT2AOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL6790513 | 0.81 | OPRD1 (0.97) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| Piperazine SCHEMBL28229145 | 0.81 | MEN1 (0.96) | OPRD1MEN1KMT2AOPRM1SLC6A4 | |
| Fluoride SCHEMBL27959930 | 0.81 | MEN1 (0.96) | OPRD1MEN1KMT2AOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL7006476 | 0.81 | MEN1 (0.96) | OPRD1MEN1KMT2AOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL11456225 | 0.81 | MEN1 (0.96) | OPRD1MEN1KMT2AOPRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022074-B2 | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2011-09-20 | — | — | US | disclosed |
| US-7960389-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |
| CN-100471844-C | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2009-03-25 | — | — | CN | disclosed |
| CN-100415729-C | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| US-7396834-B2 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2008-07-08 | — | — | US | disclosed |
| US-7253173-B2 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-08-07 | — | — | US | disclosed |
| US-7241764-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-07-10 | — | — | US | disclosed |
| US-7229994-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| CN-1269805-C | 4- (phenyl-piperazinyl-methyl) -benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | CN | disclosed |
| US-20060167004-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-07-27 | — | — | US | disclosed |
| US-20060142296-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | US | disclosed |
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-06-08 | — | — | US | disclosed |
| CN-1711251-A | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |
| CN-1711252-A | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |
| CN-1527820-A | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestional disorders | — | 2004-09-08 | — | — | CN | disclosed |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | OPRK1, TRPV1, OPRM1 | OPRD1 5/4885MEN1 3459/4885KMT2A 363/4885 |
| US-20060167004-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | TRPV1, OPRM1, OPRK1 | OPRD1 8/4885MEN1 3692/4885KMT2A 270/4885 |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | HTR2C, OPRM1, HTR3C | OPRD1 7/4885MEN1 3710/4885KMT2A 1053/4885 |
| US-20060142296-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | OPRL1, OPRM1, TRPV1 | OPRD1 8/4885MEN1 3803/4885KMT2A 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.