Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002166 | 0.82 | RORC (0.40) | TACR3RORCCNR2HSD11B1DPP4 | |
| SCHEMBL20003044 | 0.76 | RORC (0.40) | RORCNPC1RAB9AATM | |
| SCHEMBL20003139 | 0.74 | RAB9A (0.33) | RORCHSD11B1DPP4NPC1RAB9A | |
| SCHEMBL20002445 | 0.74 | RORC (0.41) | RORCHSD11B1NPC1RAB9AATM | |
| SCHEMBL20002171 | 0.74 | KMT2A (0.38) | RORCHSD11B1NPC1RAB9AATM | |
| SCHEMBL20003241 | 0.74 | RORC (0.41) | RORCHSD11B1NPC1RAB9AATM | |
| SCHEMBL20002856 | 0.74 | RORC (0.42) | RORCHSD11B1DPP4NPC1RAB9A | |
| SCHEMBL20002926 | 0.74 | RORC (0.43) | RORCDPP4KCNH2 | |
| SCHEMBL20002207 | 0.74 | RORC (0.45) | RORCNPC1RAB9AATM | |
| SCHEMBL20002924 | 0.73 | MAPK1 (0.34) | RORCHSD11B1NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |