Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12447952 | 0.73 | RAB9A (0.61) | NPC1RAB9AATMHSD11B1 | |
| SCHEMBL12447336 | 0.69 | CCR5 (0.61) | NPC1RAB9AATMHSD11B1 | |
| SCHEMBL12447948 | 0.69 | CCR5 (0.61) | NPC1RAB9AATMHSD11B1 | |
| SCHEMBL20149104 | 0.69 | RORC (0.71) | RORCPAX8 | |
| SCHEMBL16785546 | 0.66 | NPC1 (0.54) | NPC1RAB9A | |
| SCHEMBL11178698 | 0.66 | ALDH1A1 (0.58) | NPC1RAB9AATMHSD11B1 | |
| SCHEMBL12447717 | 0.65 | NAMPT (0.57) | NPC1RAB9AATM | |
| SCHEMBL20148966 | 0.65 | CCR5 (0.48) | — | |
| SCHEMBL13097359 | 0.65 | HPGD (0.56) | HSD11B1 | |
| SCHEMBL19988362 | 0.64 | HTR2B (0.64) | NPC1RAB9AATMHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |