Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003037 | 0.89 | RORC (0.38) | RORCGFERHDAC3HDAC1HDAC2 | |
| SCHEMBL20003029 | 0.87 | RORC (0.41) | RORCKDM1A | |
| SCHEMBL20002352 | 0.84 | MAPT (0.39) | RORCKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL20002167 | 0.81 | KDM1A (0.40) | RORCKDM1AEPHX2 | |
| SCHEMBL20002280 | 0.81 | TACR1 (0.40) | RORCHDAC3HDAC1HDAC2 | |
| SCHEMBL20002969 | 0.79 | NOTUM (0.45) | RORCKMT2A | |
| SCHEMBL20003049 | 0.79 | AKR1C3 (0.51) | KMT2AEPHX2CYP2C19 | |
| SCHEMBL20002669 | 0.79 | NOTUM (0.45) | RORCKMT2A | |
| SCHEMBL20002631 | 0.78 | HSD11B1 (0.33) | RORCKMT2A | |
| SCHEMBL20002664 | 0.78 | TSHR (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |