Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002981 | 0.84 | KDM4E (0.55) | NAMPTRAB9ANPC1ATMHSD11B1 | |
| SCHEMBL20002229 | 0.81 | MEN1 (0.38) | RORCRAB9ANPC1ATMMAPT | |
| SCHEMBL20002584 | 0.80 | RAB9A (0.47) | NAMPTRAB9ANPC1MAPTCYP2C9 | |
| SCHEMBL20002218 | 0.80 | SMN1; SMN2 (0.47) | RORCMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL20002209 | 0.80 | SMN1; SMN2 (0.47) | RORCMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL20003049 | 0.79 | AKR1C3 (0.51) | NPC1HSD11B1CYP2C9EPHX2ALDH1A1 | |
| SCHEMBL20002280 | 0.79 | TACR1 (0.40) | RORCHSD11B1 | |
| SCHEMBL20002957 | 0.79 | NOTUM (0.48) | RORCHSD11B1MAPTEPHX2ALDH1A1 | |
| SCHEMBL20002958 | 0.79 | NOTUM (0.48) | RORCHSD11B1MAPTEPHX2ALDH1A1 | |
| SCHEMBL20002167 | 0.79 | KDM1A (0.40) | RORCRAB9ANPC1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |