Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002584 | 0.84 | RAB9A (0.47) | KDM4EGAAPOLBSMN1; SMN2NAMPT | |
| SCHEMBL20002218 | 0.84 | SMN1; SMN2 (0.47) | KDM4EGAAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL20002209 | 0.84 | SMN1; SMN2 (0.47) | KDM4EGAAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL20003022 | 0.84 | RORC (0.49) | KDM4EGAAPOLBSMN1; SMN2NAMPT | |
| SCHEMBL20003097 | 0.81 | HSD11B1 (0.59) | KDM4ESMN1; SMN2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL20002399 | 0.80 | NAMPT (0.50) | NAMPTLMNA | |
| SCHEMBL20002698 | 0.77 | HSD11B1 (0.47) | POLBSMN1; SMN2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL20002706 | 0.77 | HSD11B1 (0.47) | POLBSMN1; SMN2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL20003082 | 0.76 | SMN1; SMN2 (0.44) | POLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL20002751 | 0.76 | NOTUM (0.42) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |