Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.33 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.30 |
| ▸ | CDK1 | P06493 | 2/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.30 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.30 |
| ▸ | ATG7 | O95352 | 1/20 | 0.30 |
| ▸ | UBA7 | P41226 | 1/20 | 0.30 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007970 | 0.84 | DNPH1 (0.38) | NAE1UBA3CCNB2CDK1CCNB1 | |
| SCHEMBL20008382 | 0.78 | ADORA2A (0.32) | CCNB2CDK1CCNB1CCNB3ATG7 | |
| SCHEMBL23080286 | 0.77 | ADORA2A (0.36) | NAE1UBA3CCNB2CDK1CCNB1 | |
| SCHEMBL20008410 | 0.77 | ATG7 (0.36) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL20008399 | 0.76 | ABL1 (0.40) | RETNAE1UBA3CCNB2CDK1 | |
| SCHEMBL20008212 | 0.76 | ADORA3 (0.34) | NAE1UBA3 | |
| SCHEMBL20008098 | 0.75 | CDK1 (0.41) | CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL23080248 | 0.74 | — | — | |
| SCHEMBL23080208 | 0.74 | ADK (0.32) | — | |
| SCHEMBL23080274 | 0.74 | CDK2 (0.38) | CDK1CDK2ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-03-11 | — | — | US | disclosed |
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | RET 3045/4885NAE1 257/4885UBA3 235/4885 |
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | ECE1, RNASE1, RCE1 | RET 3593/4885NAE1 41/4885UBA3 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.