Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.40 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | TMPRSS15 | P98073 | 6/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008675 | 0.89 | PRSS1 (0.36) | KDM4EPRSS1KLK1TMPRSS2TMPRSS15 | |
| SCHEMBL20008660 | 0.84 | F2 (0.49) | POLBPRSS1KLK1TMPRSS2PRSS2 | |
| SCHEMBL20008652 | 0.81 | F12 (0.46) | PRSS1KLK1TMPRSS2PRSS2PRSS3 | |
| SCHEMBL20008667 | 0.80 | PRSS1 (0.47) | PRSS1NR1H4KLK1TMPRSS2TMPRSS15 | |
| SCHEMBL20008691 | 0.79 | PRSS1 (0.40) | KDM4EPOLBPRSS1NR1H4KLK1 | |
| SCHEMBL4752930 | 0.77 | PRSS1 (0.61) | KDM4EPOLBPRSS1NR1H4KLK1 | |
| SCHEMBL20008669 | 0.76 | NR1H4 (0.45) | KDM4EPRSS1NR1H4KLK1TMPRSS2 | |
| SCHEMBL20008670 | 0.76 | PRSS1 (0.44) | PRSS1NR1H4KLK1TMPRSS2TMPRSS15 | |
| SCHEMBL18720203 | 0.74 | KMT2A (0.48) | PRSS1KLK1TMPRSS2PRSS2PRSS3 | |
| SCHEMBL20008699 | 0.74 | KMT2A (0.48) | PRSS1KLK1TMPRSS2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | OPRM1, OPRK1, OPRD1 | KDM4E 1535/4885POLB 1269/4885PRSS1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.