Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008672 | 0.79 | KDM4E (0.40) | PRSS1KLK1TMPRSS2TMPRSS15CASP3 | |
| SCHEMBL20008682 | 0.78 | PRSS1 (0.47) | PRSS1KLK1TMPRSS2TMPRSS15RXRA | |
| SCHEMBL20008693 | 0.70 | PRSS1 (0.42) | PRSS1KLK1TMPRSS2TMPRSS15F2 | |
| SCHEMBL20008675 | 0.68 | PRSS1 (0.36) | PRSS1KLK1TMPRSS2TMPRSS15F2 | |
| SCHEMBL20008667 | 0.68 | PRSS1 (0.47) | PRSS1KLK1TMPRSS2TMPRSS15NR1H4 | |
| SCHEMBL384743 | 0.66 | GAA (0.57) | PRSS1KLK1TMPRSS2PTGS1AKR1C3 | |
| SCHEMBL4295820 | 0.65 | KLK1 (0.47) | PRSS1KLK1TMPRSS2PTGS1AKR1C3 | |
| SCHEMBL9244144 | 0.65 | ESR1 (0.56) | RXRARXRBRXRGPTGS1MAPT | |
| SCHEMBL482856 | 0.64 | PPARA (0.51) | RXRARXRBRXRGPTGS1AKR1C3 | |
| SCHEMBL11489461 | 0.64 | GAA (0.55) | PRSS1KLK1TMPRSS2PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | OPRM1, OPRK1, OPRD1 | PRSS1 952/4885KLK1 3383/4885TMPRSS2 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.